Publications

Steatotic liver disease induces YAP/TAZ-driven cell competition that can suppress tumor initiation - Algueró-Nadal A, Mol H, Zoppolato E, Kowalczyk W, Sansores-García L, Soheily S, Hillen H, van Huffel L, Van Haele M, Corral-Ibáñez M, Hoffelner DK, van Grunsven LA, Roskams T, Govaere O, Moya IM, Halder G - Journal of Hepatology - Pubmed 

Single-cell spatial multi-omics and deep learning dissect enhancer-driven gene regulatory networks in liver zonation - Bravo Gonzalez-Blas C, Matetovici I, Hillen H, Taskiran II, Vandepoel R, Christiaens V, Sansores-Garcia L, Verboven E, Hulselmans G, Poovathingal S, Demeulemeester J, Psatha N, Mauduit D, Halder G, Aerts S - Nature Cell Biology - Pubmed

Expected and unexpected effects after systemic inhibition of Hippo transcriptional output in cancer - Baroja I, Kyriakidis NC, Halder G, Moya IM - Nature Communications - Pubmed

In Vivo Tracking and 3D Mapping of Cell Death in Regeneration and Cancer Using Trypan Blue - Procel N, Camacho K, Verboven E, Baroja I, Guerrero PA, Hillen H, Estrella-Garcia C, Vizcaino-Rodriguez N, Sansores-Garcia L, Santamaria-Naranjo A, Romero-Carvajal A, Caicedo A, Halder G, Moya IM - Cells - Pubmed

Shared enhancer gene regulatory networks between wound and oncogenic programs - Floc'hlay S, Balaji R, Stankovic D, Christiaens VM, Gonzalez-Blas CB, De Winter S, Hulselmans GJ, De Waegeneer M, Quan X, Koldere D, Atkins M, Halder G, Uhlirova M, Classen A-K, Aerts S - ELIFE - Pubmed

A novel irreversible TEAD inhibitor, SWTX-143, blocks Hippo pathway transcriptional output and causes tumor regression in preclinical mesothelioma models - Hillen H, Candi A, Vanderhoydonck B, Kowalczyk W, Sansores-Garcia L, Kesikiadou EC, Van Huffel L, Spiessens L, Nijs M, Soons E, Haeck W, Klaassen H, Smets W, Spieser SA, Marchand A, Chaltin P, Ciesielski F, Debaene F, Chen L, Kamal A, Gwaltney SL, Versele M, Halder GA - Molecular Cancer Therapeutics - Pubmed 

Hippo signaling instructs ectopic but not normal organ growth - Kowalczyk W, Romanelli L, Atkins M, Hillen H, Gonzalez-Blas CB, Jacobs J, Xie J, Soheily S, Verboven E, Moya IM, Verhulst S, de Waegeneer M, Sansores-Garcia L, van Huffel L, Johnson RL, van Grunsven LA, Aerts S, Halder G - Science - Pubmed

Regeneration Defects in Yap and Taz Mutant Mouse Livers Are Caused by Bile Duct Disruption and Cholestasis - Verboven E, Moya IM, Sansores-Garcia L, Xie J, Hillen H, Kowalczyk W, Vella G, Verhulst S, Castaldo SA, Alguero-Nadal A, Romanelli L, Mercader-Celma C, Souza NA, Soheily S, Van Huffel L, Van Brussel T, Lambrechts D, Roskams T, Lemaigre FP, Bergers G, van Grunsven LA, Halder G - 2021 - Gastroenterology - Pubmed

A Mouse Model of Cholangiocarcinoma Uncovers a Role for Tensin-4 in Tumor Progression - Di-Luoffo M, Pirenne S, Saandi T, Loriot A, Gerard C, Dauguet N, Manzano-Nunez F, Carvalhais NA S, Lamoline F, Cordi S, Konobrocka K, De Greef V, Komuta M, Halder G, Jacquemin P, Lemaigre FP - 2021 - Hepatology - Pubmed

Initiation of hepatic stellate cell activation extends into chronic liver disease - De Smet V, Eysackers N, Merens V, Dastjerd MK, Halder G, Verhulst S, Mannaerts I, van Grunsven LA - Cell Death and Didease - Pubmed

Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice. - Moya IM, Castaldo SA, Van den Mooter L, Soheily S, Sansores-Garcia L, Jacobs J, Mannaerts I, Xie J, Verboven E, Hillen H, Algueró-Nadal A, Karaman R, Van Haele M, Kowalczyk W, De Waegeneer M, Verhulst S, Karras P, van Huffel L, Zender L, Marine JC, Roskams T, Johnson R, Aerts S, van Grunsven LA, Halder G. - 2019 - Science - PubMed

Hippo-YAP/TAZ signalling in organ regeneration and regenerative medicine. - Moya IM, Halder G. - 2018 - Nat Rev Mol Cell Biol - PubMed

Modulation of the Hippo pathway and organ growth by RNA processing proteins. - Mach J, Atkins M, Gajewski KM, Mottier-Pavie V, Sansores-Garcia L, Xie J, Mills RAndrew, Kowalczyk W, Van Huffel L, Mills GB, Halder G. - 2018 - Proc Natl Acad Sci U S A - PubMed

The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models. - Vicente C, Stirparo R, Demeyer S, de Bock CE, Gielen O, Atkins M, Yan J, Halder G, Hassan BA, Cools J. - 2018 - J Hematol Oncol - PubMed

The transcription factor Grainy head primes epithelial enhancers for spatiotemporal activation by displacing nucleosomes. - Jacobs J, Atkins M, Davie K, Imrichova H, Romanelli L, Christiaens V, Hulselmans G, Potier D, Wouters J, Taskiran II, Paciello G, González-Blas CB, Koldere D, Aibar S, Halder G, Aerts S. - 2018 - Nat Genet. - PubMed

Cell Junctions in Hippo Signaling. - Karaman R, Halder G. - 2018 - Cold Spring Harb Perspect Biol - PubMed

Hippo Reprograms the Transcriptional Response to Ras Signaling. - Pascual J, Jacobs J, Sansores-Garcia L, Natarajan M, Zeitlinger J, Aerts S, Halder G, Hamaratoglu F. - 2017 - Dev Cell - PubMed

An Ectopic Network of Transcription Factors Regulated by Hippo Signaling Drives Growth and Invasion of a Malignant Tumor Model. - Atkins M, Potier D, Romanelli L, Jacobs J, Mach J, Hamaratoglu F, Aerts S, Halder G. - 2016 - Curr Biol - PubMed

The Hippo pathway in cellular reprogramming and regeneration of different organs. - Moya IM, Halder G. - 2016 - Curr Opin Cell Biol - PubMed

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. - Meng Z, Moroishi T, Mottier-Pavie V, Plouffe SW, Hansen CG, Hong AW, Park HWoo, Mo J-S, Lu W, Lu S, Flores F, Yu F-X, Halder G, Guan K-L. - 2015 - Nat Commun - PubMed

The Hippo pathway effector YAP controls mouse hepatic stellate cell activation. - Mannaerts I, Leite SBatista, Verhulst S, Claerhout S, Eysackers N, Thoen LFR, Hoorens A, Reynaert H, Halder G, van Grunsven LA. - 2015 - J Hepatol - PubMed

Differential regulation of the Hippo pathway by adherens junctions and apical-basal cell polarity modules. - Yang C-C, Graves HK, Moya IM, Tao C, Hamaratoglu F, Gladden AB, Halder G. - 2015 - Proc Natl Acad Sci U S A - PubMed

Discovering the Hippo pathway protein-protein interactome. - Moya IM, Halder G. - 2014 - Cell Res - PubMed

Tumor suppression by cell competition through regulation of the Hippo pathway. - Chen C-L, Schroeder MC, Kango-Singh M, Tao C, Halder G. - 2012 - Proc Natl Acad Sci U S A - PubMed

Modulating F-actin organization induces organ growth by affecting the Hippo pathway. - Sansores-Garcia L, Bossuyt W, Wada K-I, Yonemura S, Tao C, Sasaki H, Halder G. - 2011 - EMBO J - PubMed

The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila - Chen C-L, Gajewski KM, Hamaratoglu F, Bossuyt W, Sansores-Garcia L, Tao C, Halder G. - 2010 - Proc Natl Acad Sci U S A - PubMed

Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation. - Willecke M, Hamaratoglu F, Sansores-Garcia L, Tao C, Halder G. - 2007 - Proc Natl Acad Sci U S A - PubMed